Worth repeating: medical marijuana defeats Crohn’s Disease


Medical marijuana can manage and sometimes cause the complete remission of Crohn’s Disease symptoms like pain, inflammation, cramping and nausea.

Thousands of medical cannabis patients will tell you medical marijuana can treat and suppress the pain, inflammation, cramping and nausea of Crohn’s Disease. New studies come out every year backing up the evidence for use of the herb to treat the widespread gut ailment, whether by smoking, vaping, edibles, and other options. Patients are saying there is an alternative to toxic prescription drugs, and access to it is expanding.

The case for medical marijuana for Crohn’s Disease

The Crohn’s and Colitis Foundation of America — which notes that opioids are a treatment for Crohn’s pain — doesn’t mention the word “marijuana” or “cannabis” on their web site once.

Which is strange, because the medical history, as well as cell, animal and human trials make a rock-solid case for cannabis as an alternative to pharmaceuticals. Medical cannabis is legal in some form in 35 states, as well as several countries.

The auto-immune related disease of the digestive system is thought incurable and can often result in surgery. About 1.4 million Americans are thought to have some form of IBD, and a range of anti-inflammatories and narcotic painkillers are often prescribed.

Treating and stopping inflammatory bowel disease with existing drugs is “currently one of the biggest challenges in the field of gastroenterology,”

Researchers noted in 2011, that “A significant number of patients with IBD currently use marijuana. Most patients find it very helpful for symptom control, including patients with ulcerative colitis.”

Lab evidence for marijuana for Crohn’s

The evidence is indisputable, cannabis’ active ingredients — the cannabinoids — interact like keys in a lock with receptors on nerve cells — primarily in the brain, but also in the gut.

cannabis for crohn's disease illustration

Researchers wrote for a paper in Pharmacology in 2014 that “In ancient medicine, cannabis has been widely used to cure disturbances and inflammation of the bowel. … In a prospective placebo-controlled study, it has been shown what has been largely anticipated from anecdotal reports, i.e. that cannabis produces significant clinical benefits in patients with Crohn’s disease. The mechanisms involved are not yet clear but most likely include peripheral actions on cannabinoid receptors 1 and 2, and may also include central actions.”

In 2002, researchers noted that THC “modulates the immune response of T lymphocytes” to decrease pro-inflammatory reactions. “This may explain why THC is effective against inflammation … in multiple sclerosis, CROHN’s disease and arthritis.”

German researchers noted in 2004 that “the cannabinoid system plays an important role in inflammation of the large intestine (colon). A synthetic cannabinoid and endocannabinoids prevented experimental inflammation of the colon in mice.”

In 2013, researchers noted that pot molecule cannabidiol appears to be a gut protectant. CBD interrupts runaway inflammation in the bowel, by reducing the damage to bowel muscosa from the pro-inflammatory substance interleukin 17A.

And in 2014, researchers noted that boosting the bodies’ endocannabinoid system stopped ulcerative colitis in mice. Researchers used a custom anandamide inhibitor in the lab. Pot smoke contains anandamide analog THC.

Human Proof

A 2011 questionnaire of 291 Israeli patients found “cannabis use is common amongst patients with IBD for symptom relief, particularly amongst those with a history of abdominal surgery, chronic abdominal pain and/or a low quality of life index. … 33 per cent of patients with colitis ulcerosa and 50 per cent of patients with CROHN’s disease have used [cannabis] to relieve symptoms related to inflammatory bowel disease, including abdominal pain, diarrhoea and reduced appetite.”

Source: sfgate.com

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